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desvenlafaxine will increase the degree or effect of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by nearly 50%; no dosage adjustment necessary with desvenlafaxine doses seven consecutive days quickly prior